ParkinsonCanadaV1, Main, Exploration, bibRecord, 000514

The Effect of Statins on Blood Gene Expression in COPD

Identifieur interne : 000514 ( Main/Exploration ); précédent : 000513; suivant : 000515

The Effect of Statins on Blood Gene Expression in COPD

Auteurs : Ma N Obeidat [Canada] ; Nick Fishbane [Canada] ; Yunlong Nie [Canada] ; Virginia Chen [Canada] ; Zsuzsanna Hollander [Canada] ; Scott J. Tebbutt [Canada] ; Yohan Bossé [Canada] ; Raymond T. Ng [Canada] ; Bruce E. Miller [États-Unis] ; Bruce Mcmanus [Canada] ; Stephen Rennard [États-Unis] ; Peter D. Paré [Canada] ; Don D. Sin [Canada]

Source :

PLoS ONE [ 1932-6203 ] ; 2015.

RBID : PMC:4604084

Abstract

Background

COPD is currently the fourth leading cause of death worldwide. Statins are lipid lowering agents with documented cardiovascular benefits. Observational studies have shown that statins may have a beneficial role in COPD. The impact of statins on blood gene expression from COPD patients is largely unknown.

Objective

Identify blood gene signature associated with statin use in COPD patients, and the pathways underpinning this signature that could explain any potential benefits in COPD.

Methods

Whole blood gene expression was measured on 168 statin users and 451 non-users from the ECLIPSE study using the Affymetrix Human Gene 1.1 ST microarray chips. Factor Analysis for Robust Microarray Summarization (FARMS) was used to process the expression data. Differential gene expression analysis was undertaken using the Linear Models for Microarray data (Limma) package adjusting for propensity score and surrogate variables. Similarity of the expression signal with published gene expression profiles was performed in ProfileChaser.

Results

25 genes were differentially expressed between statin users and non-users at an FDR of 10%, including LDLR, CXCR2, SC4MOL, FAM108A1, IFI35, FRYL, ABCG1, MYLIP, and DHCR24. The 25 genes were significantly enriched in cholesterol homeostasis and metabolism pathways. The resulting gene signature showed correlation with Huntington’s disease, Parkinson’s disease and acute myeloid leukemia gene signatures.

Conclusion

The blood gene signature of statins’ use in COPD patients was enriched in cholesterol homeostasis pathways. Further studies are needed to delineate the role of these pathways in lung biology.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604084

DOI: 10.1371/journal.pone.0140022
PubMed: 26462087
PubMed Central: 4604084

Affiliations:

Le document en format XML

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</nlm:aff>
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<author><name sortKey="Sin, Don D" sort="Sin, Don D" uniqKey="Sin D" first="Don D." last="Sin">Don D. Sin</name>
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</nlm:aff>
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</nlm:aff>
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<front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title>
<p>COPD is currently the fourth leading cause of death worldwide. Statins are lipid lowering agents with documented cardiovascular benefits. Observational studies have shown that statins may have a beneficial role in COPD. The impact of statins on blood gene expression from COPD patients is largely unknown.</p>
</sec>
<sec id="sec002"><title>Objective</title>
<p>Identify blood gene signature associated with statin use in COPD patients, and the pathways underpinning this signature that could explain any potential benefits in COPD.</p>
</sec>
<sec id="sec003"><title>Methods</title>
<p>Whole blood gene expression was measured on 168 statin users and 451 non-users from the ECLIPSE study using the Affymetrix Human Gene 1.1 ST microarray chips. Factor Analysis for Robust Microarray Summarization (FARMS) was used to process the expression data. Differential gene expression analysis was undertaken using the Linear Models for Microarray data (Limma) package adjusting for propensity score and surrogate variables. Similarity of the expression signal with published gene expression profiles was performed in ProfileChaser.</p>
</sec>
<sec id="sec004"><title>Results</title>
<p>25 genes were differentially expressed between statin users and non-users at an FDR of 10%, including <italic>LDLR</italic>
, <italic>CXCR2</italic>
, <italic>SC4MOL</italic>
, <italic>FAM108A1</italic>
, <italic>IFI35</italic>
, <italic>FRYL</italic>
, <italic>ABCG1</italic>
, <italic>MYLIP</italic>
, and <italic>DHCR24</italic>
. The 25 genes were significantly enriched in cholesterol homeostasis and metabolism pathways. The resulting gene signature showed correlation with Huntington’s disease, Parkinson’s disease and acute myeloid leukemia gene signatures.</p>
</sec>
<sec id="sec005"><title>Conclusion</title>
<p>The blood gene signature of statins’ use in COPD patients was enriched in cholesterol homeostasis pathways. Further studies are needed to delineate the role of these pathways in lung biology.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Decramer, M" uniqKey="Decramer M">M Decramer</name>
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La maladie de Parkinson au Canada (serveur d'exploration)

The Effect of Statins on Blood Gene Expression in COPD

The Effect of Statins on Blood Gene Expression in COPD

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Abstract

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	La maladie de Parkinson au Canada (serveur d'exploration)
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